Category: news

The CCR Retreat is back! Hata Lab research was well represented by posters from Samar, Jamie, Hideko, Chendi and Justine.

Aya, Jess and Satoshi’s manuscript “Analysis of lorlatinib analogs reveals a roadmap for targeting diverse compound resistance mutations in ALK-positive lung cancer” is now published in Nature Cancer! This collaboration with the Pfizer lorlatinib team presents specific strategies for targeting different classes of ALK compound resistance mutations.

We say farewell to Usman who is attending the University of Rochester for an MD-PhD program. Best wishes to you in your future endeavors – we will miss you!

The return of the 9th Annual Lungstrong 5K as a live and in person event was a success – thanks to everyone who came out to run and walk in support of lung cancer research at MGH! 

We say farewell to Linh who is a MD-PhD Candidate at Thomas Jefferson University. Best wishes to you in your future endeavors – we will miss you!

2022 AACR Annual Meeting News: Kipp Weiskopf, Whitehead Fellow at MIT, presented a poster “Targeted therapies prime lung cancer cells for macrophage-mediated destruction” highlighting work done in collaboration with the Hata Lab that suggests that blocking CD47 on tumor cells may improve the response to lung cancer targeted therapies.

The Hata lab was well represented with two oral presentations at the 2022 AACR Annual Meeting in New Orleans. Hideko Isozaki presented “Impact of therapy induced APOBEC3A mutagenesis on tumor evolution in non small cell lung cancer” highlighting a new mechanism by which targeted therapies may induce mechanisms that facilitate evolution of acquired resistance. Chendi Li presented “LKB1 loss rewires JNK-induced apoptotic protein dynamics through NUAKs and sensitizes KRAS-mutant NSCLC to combined KRAS G12C + MCL-1 blockade,” describing a novel mechanism by which LKB1 loss leads to a targetable therapeutic vulnerability in KRAS mutant lung cancers and providing rationale for clinical testing of KRAS G12C + MCL-1 inhibitors in this patient population.”

We say farewell to Haichuan who will be traveling back to China to be with his family. Best wishes to you in your future endeavors – we will miss you!

Jamie’s manuscript “Stitchr: stitching coding TCR nucleotide sequences from V/J/CDR3 information” is now published in Nucleic Acid Research!