Investigating the mechanisms of drug sensitivity and resistance to targeted therapies for lung cancer.
Tumor Evolution during treatment
How do tumor cells evolve during treatment? Can we slow or halt the evolution of acquired drug resistance?
Tumor heterogeneity
Are all cells within a tumor created equal? Why are some cells killed by therapy while other are able to survive?
Acquired drug resistance
Why do targeted therapies stop working? Can we develop new therapies to overcome drug resistance?
Novel targeted therapy approaches for lung cancer
Can we combine orthogonal targeted therapy and immunotherapy approaches to better fight lung cancer?
Featured Publication
LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers
Published May 2, 2025
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Mission
Our mission is to advance the development of new therapies for patients with lung cancer through scientific discovery of the molecular mechanisms of drug sensitivity and resistance, understanding tumor evolution during treatment, and identification of targetable vulnerabilities to guide investigation of novel therapeutic strategies.
We are a diverse group of physicians & scientists with expertise in cell biology, pharmacology, genetics, immunology and computational biology. We are currently recruiting at all levels - if you would like to join our team, please contact us.
Meet the Team
News — December 14, 2024
IASLC
Aaron speaks at the 2024 Hot Topic in Basic & Translational Science: Tolerance and Resistance to Targeted Therapy in NSCLC conference sponsored by IASLC.
Go to NewsNews — December 5, 2024
BTC
The Hata Lab will be a part of the new PoweRD 2 Cure ALK+ Lung Cancer TeamLab announced by Breakthrough Cancer. We will focus on understanding and eliminating residual disease…
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We are looking for people to partner with us in our mission to improve treatments for patients with lung cancer.
Join Us Support UsSupporters
We are privileged to partner with a number of individuals and organizations who support our research. We are grateful for their dedication to helping us in the fight against lung cancer.
Hata Lab
MGH Cancer Center, Room 7.310
149 13th Street, Charlestown, MA 02129
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