IAAO

Aaron speaks at the 2023 International Academy for Advanced Oncology meeting in Tokyo. Thanks to Dr. Nori Takanashi and Dr. Taro Mizayaki and C-FINDS for their hospitality and organizing such a terrific meeting! Such a great opportunity to make new Japanese friends and reconnect with MGH alumns Dr. Aya Shiba (Hata Lab), Dr. Ryohei Katayama (Engelman Lab) and Dr. Hiro Ebi (Engelman Lab).

APOBEC manuscript is published!

Hideko’s manuscript “Therapy-induced APOBEC3A drives evolution of persistent cancer cells” is now published in Nature! We show that lung cancer targeted therapies induced APOBEC3A, which drives evolution of drug tolerance and resistance. This was terrific collaborative effort with the Lawrence Group, Dyson Lab, Zou Lab, Ott Lab, Getz Lab, MGH Thoracic Oncology and many others.
Isozaki H, Sakhtemani R, Abbasi A, Nikpour N, Stanzione M, Oh S, Langenbucher A, Monroe S, Su W, Cabanos HF, Siddiqui FM, Phan N, Jalili P, Timonina D, Bilton S, Gomez-Caraballo M, Archibald HL, Nangia V, Dionne K, Riley A, Lawlor M, Banwait MK, Cobb RG, Zou L, Dyson NJ, Ott CJ, Benes C, Getz G, Chan CS, Shaw AT, Gainor JF, Lin JJ, Sequist LV, Piotrowska Z, Yeap BY, Engelman JA, Lee JJK, Maruvka YE, Buisson R, Lawrence MS, Hata AN. Therapy-induced APOBEC3A drives evolution of persistent cancer cells. Nature. 2023 Jul 5. doi: 10.1038/s41586-023-06303-1. Online ahead of print. PMID: 37407818