Month: November 2019

Hideko joined the Hata Lab in June 2017. She completed Ph.D. at Okayama University in the Department of Hematology, Oncology and Respiratory Medicine where she focused on the mechanisms of drug resistance to molecularly target inhibitor in lung cancer harboring the EML4-ALK fusion gene. A number of mechanisms of drug resistance to target therapy have been identified such as her previous study, yet little is know what’s happening on during a course of treatment. She currently interested in how cancer cells evolve from drug tolerant persister status and acquire the resistance in non-small cell lung cancer with EGFR mutations or ALK rearrangements. To define the mechanisms of cancer evolution during target therapy, she is excitedly exploring the linkage pathway between innate immune response and genomic instability. This project will lead to prevent acquired drug resistance and provide new therapeutic strategies. Outside the lab, Hideko’s favorite things are playing kyudo (archery) and piano.

Chendi received her Bachelor of Science degree in Biological Science as an honors graduate from Shaanxi Normal University, China. She then completed a PhD in the Department of Biochemistry at Boston University School of Medicine (BUSM) where her research in the laboratory of Dr. Stephen Farmer focused on understanding the mechanisms of energy expenditure and stem cell fate in brown adipose tissue. Chendi joined the Hata laboratory as a research fellow in June 2017 in order to pursue a new direction in translational cancer research. One of Chendi’s research interests is to identify novel targeted therapeutic strategies for KRAS mutant NSCLC, a subset of lung cancers that have so remained refractory to targeted approaches. She is particularly interested in targeting vulnerability of subsets of KRAS mutant NSCLC bearing different co-occurring mutations. In addition, Chendi is interested in deciphering the evolution of lung cancer heterogeneity by utilizing computational and “omic” approaches. Outside work, Chendi is training as a Chinese martial artist, is a professional Erhu player and a certified scuba diver. Chendi also has a passion for different types of music, especially classic rock!

Jamie completed his Bachelor and Masters at the University of Sussex, before undertaking his PhD at the University College London. There he worked with Professors Benjamin Chain and Mahdad Noursadeghi, developing methods for high-throughput sequencing and analysis of T cell receptor (TCR) repertoires. He moved from London to MGH to work with Mark Cobbold, exploring immunopeptidomes and TCR repertoires in a range of cancers. Staying within the department, he moved to the Hata lab in September of 2019, where he is working on developing immunotherapies to treat ALK positive lung cancers.