Month: April 2021
KRAS G12C resistance
Tanaka N*, Lin JJ*, Li C*, Ryan MB, Zhang J, Kiedrowski LA, Michel AG, Syed MU, Fella KA, Sakhi M, Baiev I, Juric D, Gainor JF, Klempner SJ, Lennerz JK, Siravegna G, Bar-Peled L, Hata AN*, Heist RS*, Corcoran RB*. Clinical acquired resistance to KRASG12C inhibition through a novel KRAS switch-II pocket mutation and polyclonal alterations converging on RAS-MAPK reactivation. Cancer Discov. 2021 Apr 6:candisc.0365.2021. doi: 10.1158/2159-8290.CD-21-0365. Online ahead of print. PMID: 33824136
