Aaron elected to ASCI
Aaron has been elected to the American Society for Clinical Investigation (ASCI)!
Author: Aaron Hata
NVL-655
We are excited to report the results of this collaboration with Nuvalent at the 2022 EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics: NVL-655 shows activity against lorlatinib-resistant ALK NSCLC experimental models harboring compound ALK resistance mutations.
KRAS-LKB1 bioRxiv
Chendi’s manuscript on the MCL-1 dependency of KRAS-LKB1 mutant NSCLC is now posted to bioRxiv! This describes a novel mechanism by which LKB1 regulates apoptotic signaling via NUAK1/2 and JNK.
Return of the CCR Retreat!
The CCR Retreat is back! Hata Lab research was well represented by posters from Samar, Jamie, Hideko, Chendi and Justine.
Lorlatinib analogs manuscript is published!
Aya, Jess and Satoshi’s manuscript “Analysis of lorlatinib analogs reveals a roadmap for targeting diverse compound resistance mutations in ALK-positive lung cancer” is now published in Nature Cancer! This collaboration with the Pfizer lorlatinib team presents specific strategies for targeting different classes of ALK compound resistance mutations.
Shiba-Ishii A, Johnson TW, Dagogo-Jack I, Mino-Kenudson M, Johnson TR, Wei P, Weinrich SL, McTigue MA, Walcott MA, Nguyen-Phuong L, Dionne K, Acker A, Kiedrowski LA, Do A, Peterson JL, Barth JL, Yeap BW, Gainor JF, Lin JJ, Yoda S, Hata AN. Analysis of lorlatinib analogs reveals a roadmap for targeting diverse compound resistance mutations in ALK-positive lung cancer. Nature Cancer. 2022 Jun 20. doi: 10.1038/s43018-022-00399-6. Online ahead of print.PMID: 35726063
Heather JM, Spindler MJ, Herrero-Alonso M, Shui YI, Millar DG, Johnson DS, Cobbold M, Hata AN. Stitchr: stitching coding TCR nucleotide sequences from V/J/CDR3 information. Nucleic Acids Research. March 24 2022, online ahead of print. doi: 10.1093/nar/gkac190. PMID 35325179
Stitchr manuscript is published
Jamie’s manuscript “Stitchr: stitching coding TCR nucleotide sequences from V/J/CDR3 information” is now published in Nucleic Acid Research!
2020 Lungstrong 5K
The 2020 LungStrong 5K is going virtual! To sign up, register at https://runsignup.com/Race/Register?raceId=95114 and then run your 5K between October 25th and November 8th. All money raised will directly benefit lung cancer research in the Center for Thoracic Cancers at MGH!
Ann Oncol 2020
Lin JJ, Liu SV, McCoach CE, Zhu VW, Tan AC, Yoda S, Peterson J, Do A, Prutisto-Chang K, Dagogo-Jack I, Sequist LV, Wirth LJ, Lennerz JK, Hata AN, Mino-Kenudson M, Nardi V, Ou SI, Tan DS, Gainor JF. Mechanisms of Resistance to Selective RET Tyrosine Kinase Inhibitors in RET Fusion-Positive Non-Small Cell Lung Cancer. Ann Oncol. 2020 Sep 29:S0923-7534(20)42465-2. doi: 10.1016/j.annonc.2020.09.015. PMID:33007380
