News
March 14, 2024
Our collaboration with the Weiskopf lab on redirecting macrophages to target persister cells in oncogene-addicted lung cancers is now published in JCI: Targeted therapies prime oncogene-driven lung cancers for macrophage-mediated destruction.
January 18, 2024
Hideko presents on her most recent work “APOBEC3A drives tumor evolution through activation of ERVs in non-small cell lung cancer” at the the 5th International Conference on Base Editing, Prime Editing & Related Enzymes (Deaminet 2024).
October 18, 2023
Aaron presents at the Regulatory Networks in Health and Disease Seminar series in the Department of Pharmacology and Cancer Biology at Duke Med. Thanks to Kris Wood for hosting a wonderful visit with Duke PCB faculty and students!
October 13, 2023
Chendi presents posters on her most recent work at the 2023 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics: “Non-genetic determinants driving sub-clonal resistance to KRAS G12C combination therapies in KRAS mutant non-small cell lung cancer” and “Aurora Kinase A inhibition overcomes adaptive resistance to KRAS G12C inhibitor by G1-checkpoint induced apoptosis in KRAS non-small cell lung cancer”.
September 28, 2023
Aaron was a featured speaker for the “Art of Scientific Speaking” at the 2023 KF-CCR Annual Retreat!
September 27, 2023
2023 Krantz Family Center for Cancer Research Annual Retreat at the Boston Museum of Science!
September 22, 2023
Aaron gives an Elkins Lecture at the Winship Cancer Center at Emory University. Thank you to Dr. Shi-Yong Sun for the invitation and hosting such an amazing visit!
August 4, 2023
We say farewell to Luke who will be attending the University of Utah in the Molecular Biology PhD program. Best wishes to you in your future endeavors – we will miss you!
August 4, 2023
We say farewell to Sarah who will be starting as a research technician for lymphoma research in the Roth Lab at Weill Cornell Medicine. Best wishes to you in your future endeavors – we will miss you!
July 31, 2023
Welcome to Lauren Highfield who joins our group as a research technician!
July 28, 2023
Aaron speaks at the 2023 International Academy for Advanced Oncology meeting in Tokyo. Thanks to Dr. Nori Takanashi and Dr. Taro Mizayaki and C-FINDS for their hospitality and organizing such a terrific meeting! Such a great opportunity to make new Japanese friends and reconnect with MGH alumns Dr. Aya Shiba (Hata Lab), Dr. Ryohei Katayama (Engelman Lab) and Dr. Hiro Ebi (Engelman Lab).
July 14, 2023
We say farewell to Susanna who will be attending NYU for a PhD in Chemistry. Best wishes to you in your future endeavors – we will miss you!
July 12, 2023
MGB Press Release: “Mass General Cancer Center Researchers Pinpoint Protein Tied to Drug Resistance in Patients with Lung Cancer.”
July 5, 2023
Hideko’s manuscript “Therapy-induced APOBEC3A drives evolution of persistent cancer cells” is now published in Nature! We show that lung cancer targeted therapies induced APOBEC3A, which drives evolution of drug tolerance and resistance. This was terrific collaborative effort with the Lawrence Group, Dyson Lab, Zou Lab, Ott Lab, Getz Lab, MGH Thoracic Oncology and many others.
June 5, 2023
Welcome to Ishmarie Colón & Shane Dancer who join our group as a research technicians.
May 19, 2023
We say farewell to Sarah who will be attending Yale University as a graduate student. Best wishes to you in your future endeavors – we will miss you!
May 3, 2023
Aaron teamed up with ALK NSCLC advocate and patient Colleen Ziegler at CenterStage 2023 at the MFA to highlight the importance of “bedside-to-bench” research at the MGH Cancer Center.
April 18, 2023
AACR Annual Meeting 2023: Chendi presents her posters “Chromatin modification driving sub-clonal resistance to KRAS G12C combination therapies in KRAS mutant non-small cell lung cancer” and “Aurora kinase A inhibition overcome adaptive resistance to KRAS G12C inhibitor by G1-checkpoint induced apoptosis in KRAS non-small cell lung cancer.”
April 16, 2023
AACR Annual Meeting 2023: Hideko presents her poster “Epigenetic regulation of APOBEC3A mutagenesis and tumor evolution during targeted therapy in non-small cell lung cancer.”
March 17, 2023
Congratulations to Wafa for passing her Preliminary Qualifying Exam for the Harvard BBS Program today!
March 14, 2023
Aaron speaks at the University of Colorado Cancer Center. Thank you to Dr. Sabrina Spencer for hosting. A great opportunity to make new friends and reconnect with former colleagues and trainees!
March 6, 2023
Check out a new manuscript “Targeted therapies prime oncogene-driven lung cancers for macrophage-mediated destruction” now posted to bioRxiv! This is the product of a terrific collaboration with the Weiskopf lab at MIT.
February 10, 2023
Aaron has been elected to the American Society for Clinical Investigation (ASCI)!
November 18, 2022
We say farewell to Danielle who will be attending a Software Bootcamp at General Assembly. Best wishes to you in your future endeavors – we will miss you!
October 27, 2022
We are excited to report the results of this collaboration with Nuvalent at the 2022 EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics: NVL-655 shows activity against lorlatinib-resistant ALK NSCLC experimental models harboring compound ALK resistance mutations.
September 30, 2022
Chendi’s manuscript on the MCL-1 dependency of KRAS-LKB1 mutant NSCLC is now posted to bioRxiv! This describes a novel mechanism by which LKB1 regulates apoptotic signaling via NUAK1/2 and JNK.
August 10, 2022
We say farewell to Justine who has joined Accretio Management as a Life Sciences Associate. Best wishes to you in your future endeavors – we will miss you!
July 25, 2022
We say farewell to Adam who will be getting his masters in Medical Sciences at Boston University school of medicine. Best wishes to you in your future endeavors – we will miss you!
July 18, 2022
Welcome to Anahita Nimbalkar who joins our group as a research technician.
July 11, 2022
Welcome to Grace Kelley who joins our group as a research technician on the model development team.
June 22, 2022
The CCR Retreat is back! Hata Lab research was well represented by posters from Samar, Jamie, Hideko, Chendi and Justine.
June 20, 2022
Aya, Jess and Satoshi’s manuscript “Analysis of lorlatinib analogs reveals a roadmap for targeting diverse compound resistance mutations in ALK-positive lung cancer” is now published in Nature Cancer! This collaboration with the Pfizer lorlatinib team presents specific strategies for targeting different classes of ALK compound resistance mutations.
June 6, 2022
Welcome to Emily Hensley who joins our group as a research technician on the model development team.
May 26, 2022
We say farewell to Usman who is attending the University of Rochester for an MD-PhD program. Best wishes to you in your future endeavors – we will miss you!
May 15, 2022
The return of the 9th Annual Lungstrong 5K as a live and in person event was a success – thanks to everyone who came out to run and walk in support of lung cancer research at MGH!
May 2, 2022
We say farewell to Linh who is a MD-PhD Candidate at Thomas Jefferson University. Best wishes to you in your future endeavors – we will miss you!
April 11, 2022
2022 AACR Annual Meeting News: Kipp Weiskopf, Whitehead Fellow at MIT, presented a poster “Targeted therapies prime lung cancer cells for macrophage-mediated destruction” highlighting work done in collaboration with the Hata Lab that suggests that blocking CD47 on tumor cells may improve the response to lung cancer targeted therapies.
April 11, 2022
The Hata lab was well represented with two oral presentations at the 2022 AACR Annual Meeting in New Orleans. Hideko Isozaki presented “Impact of therapy induced APOBEC3A mutagenesis on tumor evolution in non small cell lung cancer” highlighting a new mechanism by which targeted therapies may induce mechanisms that facilitate evolution of acquired resistance. Chendi Li presented “LKB1 loss rewires JNK-induced apoptotic protein dynamics through NUAKs and sensitizes KRAS-mutant NSCLC to combined KRAS G12C + MCL-1 blockade,” describing a novel mechanism by which LKB1 loss leads to a targetable therapeutic vulnerability in KRAS mutant lung cancers and providing rationale for clinical testing of KRAS G12C + MCL-1 inhibitors in this patient population.”
March 31, 2022
We say farewell to Haichuan who will be traveling back to China to be with his family. Best wishes to you in your future endeavors – we will miss you!
March 24, 2022
Jamie’s manuscript “Stitchr: stitching coding TCR nucleotide sequences from V/J/CDR3 information” is now published in Nucleic Acid Research!
March 18, 2022
We say farewell to Satoshi who has joined Tango Therapeutics as a Principal Scientist. Best wishes to you in your future endeavors – we will miss you!
March 1, 2022
We welcome Radhika Koranne as a new Post-Doc to our lab!
January 11, 2022
We say farewell to Farrah who has moved onto an industry position with Novartis Institutes for Biomedical Research (NIBR) as a Research Scientist for in vivo pharmacology and oncology. Best wishes to you in your future endeavors – we will miss you!
![stitchr image[1]](https://hatalab.mgh.harvard.edu/wp-content/uploads/2022/01/stitchr-image1-pdf.jpg)
December 22, 2021
Our manuscript describing Stitchr, a tool for generating full length TCR sequences from minimal V/J/CDR3 information, is now posted on bioRxiv. Congratulations to Jamie and the team!
December 6, 2021
Welcome to Katie Parker who joins our group as research technician!
November 8, 2021
Haichuan’s manuscript describing how CAF heterogeneity impacts the response to lung cancer targeted therapies is now published in Cancer Cell!
October 4, 2021
Welcome to Luke Boland who joins our group as a research technician.
August 20, 2021
We say farewell to Marta who has joined a lab studying Sezary Sindrome. Best wishes to you in your future endeavors – we will miss you!
August 11, 2021
The Hata lab enjoyed a nice lab retreat today at Blue Hills Reservation and a game of mini golf!
July 16, 2021
Our manuscript describing an approach to targeting ALK compound resistance mutations that arise after lorlatinib treatment is now post on bioRxiv. This was a terrific team effort led by Aya, Satoshi and Jess!
July 15, 2021
Welcome to Susanna Monroe & Danielle Colucci who join our group as research technicians.
June 30, 2021
We say farewell to Chelsi & Naveed who will be attending Stony Brook University! Best wishes to you both in your future endeavors – we will miss you!
June 4, 2021
Welcome to Sarah Clark & Sarah Reeves who join our group as both research technicians on the model development team.
June 2, 2021
Welcome to Michelle Cho who joins our group as a research technician.
June 1, 2021
We say farewell to Nat & Makeba. Nat has joined the discovery analytics team at BlueRock Therapeutics, and Makeba who will be attending the SUNY Upstate Medical University. Best wishes to you in your future endeavors – we will miss you!
March 21, 2021
We are now recruiting at all levels! Please see our job postings for a post-doctoral fellow, a research technician to study tumor evolution, a research technician to study tumor microenvironment, and a research technician to study novel T cell therapies for ALK lung cancer, and a research technician for our model development team. For more information, contact us.
March 20, 2021
We say farewell to Aya & Wafa. Aya will be at the University of Tsukuba as a faculty member of medicine and Wafa will be attending Harvard Medical school as a graduate student! Best wishes to you in your future endeavors – we will miss you!
March 8, 2021
Our paper on mechanisms of resistance crizotinib and lorlatinib in ROS1 fusion-positive lung cancer is now available in Clinical Cancer Research. A true translational team effort!
March 5, 2021
Welcome to Farrah Wakefield who joins our group as a research technician on the model development team.
January 11, 2021
Our manuscript on APOBEC3A and evolution of drug resistance is now posted on bioRxiv. Congrats to Hideko and the entire team!
January 6, 2021
Following COVID-19 guidelines, we took our annual holiday party virtual and had fun unwrapping our Secret Santa presents!
December 7, 2020
Welcome to Adam Acker who joins our group as a research technician on the model development team.
November 17, 2020
Congratulations to Hideko for receiving a Pilot Grant award from the Lung Cancer Research Foundation to study the role of APOBEC3A in evolution of acquired drug resistance!
November 2, 2020
Welcome to Marta Herrero Alonso who joins our group as a research technician.
October 1, 2020
The 2020 LungStrong 5K is going virtual! To sign up, register at https://runsignup.com/Race/Register?raceId=95114 and then run your 5K between October 25th and November 8th. All money raised will directly benefit lung cancer research in the Center for Thoracic Cancers at MGH!
September 3, 2020
After being delayed by COVID travel restrictions, Justine joins our group from Belgium, where she recently completed her PhD in the laboratory of Dr. Akeila Bellahcène at the University of Liege.
July 30, 2020
We say farewell to Aislinn & Audris. Aislinn will be attending Brandeis University as a masters student & Audris will be a Senior Clinical Operations Specialist at Syneos Health! Best wishes to you both in your future endeavors – we will miss you!
July 1, 2020
We welcome Catherine Meador to our group! Catherine is a clinical fellow in the combined DFCI/MGH Hematology-Oncology program. She received her MD PhD from Vanderbilt University where she worked with William Pao and Christine Lovly, and completed her Internal Medicine residency training at BWH.
July 1, 2020
Welcome to our newest technicians! Linh is a recent graduate of Dickinson College and Usman is a recent graduate of Tufts University.
June 30, 2020
We say farewell to Kristin & Kylie. Kylie will be attending New York University as a MD-Ph.D. candidate! Best wishes to you both in your future endeavors – we will miss you!
June 1, 2020
While we were shut down, we said good-bye to Li, Pranav, Eunice, and Yi. Best wishes to all of you in your future endeavors – we will miss you!
June 1, 2020
The lab is back open! We have been given the approval to restart our experiments while following strict social distancing and safety measures outlined by the hospital.
April 13, 2020
We are continuing our science on-line – lab meetings, journal clubs, book club, data analysis, and project planning all via Zoom.
April 9, 2020
Congratulations to Chendi for receiving a Ruth L. Kirschstein National Research Service Award (NRSA) Postdoctoral Fellowship from the NCI to study targeted therapies for KRAS mutant lung cancer!
April 1, 2020
A big thanks to Chelsi, Naveed and Satoshi who are maintaining our patient-derived cell cultures and PDX models during the shutdown.
March 20, 2020
Due to COVID-19, we have had to temporarily shut down the lab. Please stay safe and healthy everyone!
February 5, 2020
We say farewell to Heidie & Nicole. Nicole will be a Clinical Research Coordinator, MGH. Best wishes to you in your future endeavors – we will miss you!
November 19, 2019
Congratulations to Hideko for being awarded a MGH ECOR Fund for Medical Discovery Postdoctoral Fellowship Award for her work on evolution of resistance of EGFR mutant lung cancer!
October 16, 2019
Diane Legg, founder of LUNGSTRONG and long-time supporter of the MGH Thoracic Group visits our lab. Thank you Diane for all of your support of our research!
September 4, 2019
Ammal is heading off to graduate school at UCSD. We wish her success in her future studies and look forward to opportunities to collaborate in the future!
August 12, 2019
Wafa Malik joins us on August 12, 2019 from Mt. Holyoke College where she majored in Biochemistry.
June 10, 2019
Makeba Walcott joins us on June 10, 2019 from Vassar College where she majored in Biochemistry.
June 3, 2019
Naveed Nikpour joins us on June 3, 2019 from Vassar College where he majored in Biochemistry and History.
April 8, 2019
Aya Shiba joins us from Tsukuba University in Japan, where she is an Assistant Professor in the Laboratory of Diagnostic Pathology under Professor Masayuki Noguchi.
March 15, 2019
Yi Shen joins us from the Third Affiliated Hospital of Soochow University, where she is an Attending Pulmonologist
November 19, 2018
Pranav Gupta joins us from St. John’s University where he recently completed his PhD in Dr. Zhe-Sheng Chen’s lab.
